Technology
HPLC-UV purity and LC-MS/MS identity confirmation, from a US-based lab, with every method documented on the COA.
| Feature | Lab A | Lab B | Precision MS ✓ Best Choice |
|---|---|---|---|
| Location | Overseas (EU) | US | US-Based |
| Technology | HPLC / Basic MS | HPLC Only | LC-MS/MS and HPLC-UV |
| Turnaround Time | Variable / Unknown | 3–5 Business Days | 3 Business Days |
| Price | ~$120+ | $250+ | From $249 |
| Isomer Detection | Limited | Cannot distinguish | Full MS/MS fragmentation |
| Certificate of Analysis | Basic report | Standard certificate | Full certificate + methodology |
Every alternative forces a tradeoff. We eliminate the tradeoff entirely.
Cheap but Risky
Fast. Affordable. Precise.
Reliable but Slow & Costly
Labs that rely on HPLC-UV alone measure only UV absorption. That gives you purity, but it cannot tell the difference between compounds that share the same molecular weight. We run both: HPLC-UV for purity, LC-MS/MS for identity.
Real example: Enclomiphene and Clomiphene are isomers with identical molecular weights. HPLC sees them as the same compound. LC-MS/MS uses mass fragmentation patterns - a molecular "fingerprint" - to distinguish them definitively.
The difference in plain English:
HPLC tells you something is there. LC-MS/MS tells you exactly what it is - down to parts-per-billion.
UV absorption only · Cannot distinguish isomers · Higher detection limit · Single-dimension separation
UV purity plus molecular fingerprinting · Isomer-level precision · Parts-per-billion sensitivity · Dual-stage mass filtering
Liquid Chromatography–Mass Spectrometry/Mass Spectrometry
Two-stage mass filtering for molecular fingerprinting. Identifies compounds to parts-per-billion sensitivity. Distinguishes isomers HPLC cannot.
Learn More →Validated methods with calibration curves and QC standards
Every test runs with documented calibration curves, certified reference standards from Sigma-Aldrich, and quality control checks. Methods, instrumentation, and reference standards are described on each COA.
Learn More →Full certificate with compound identification, purity, and quantification data
Detailed CoA includes chromatographic data, mass spectra, calculated purity, net content, R² values, and analyst notes. Verifiable and publicizable.
Learn More →Typically 3 business days from the date your sample is received
You get an email when your sample checks in and again when your COA is ready. Expedited processing can be selected on your intake form.
Learn More →"Fast turnaround and a clear Certificate of Analysis. Exactly what our customers expect from us."
Research Vendor
Northeast US
"Switched labs. Faster results, and the LC-MS/MS data is far more detailed than anything we were getting before."
Compound Supplier
Texas
"The ability to distinguish Enclomiphene from Clomiphene with MS/MS fragmentation is a game-changer. No other affordable lab offers this."
Lab Manager
Florida